Leavitt D D
Department of Radiology, University of Utah Medical Center, Salt Lake City 84132.
Radiat Res. 1991 May;126(2):127-31.
The distribution of the dose to the head of a primate phantom due to 55-MeV proton irradiation was calculated using a clinical radiotherapy treatment planning system, with anatomic definition through computerized tomography scans. Dose profiles, isodose distributions, and differential and integral dose-volume histograms are used to describe the probable proton dose to the brain of rhesus monkeys, irradiated over two decades ago, in which brain tumors have now developed. The dose analysis shows that 59% of the brain received a dose in excess of the reference surface dose, and that portions of the brain received doses greater than 300% of the reference surface dose. The regions of high dose are illustrated in isodose distributions. This information may be useful in evaluating potential tumor induction following radiation exposure.
使用临床放射治疗治疗计划系统，通过计算机断层扫描进行解剖学定义，计算了55 MeV质子辐照对灵长类动物模型头部的剂量分布。剂量曲线、等剂量分布以及微分和积分剂量体积直方图用于描述二十多年前接受辐照的恒河猴大脑可能接受的质子剂量，这些猴子现在已经出现了脑肿瘤。剂量分析表明，59%的大脑接受的剂量超过参考表面剂量，并且大脑的部分区域接受的剂量大于参考表面剂量的300%。高剂量区域在等剂量分布中得到了说明。这些信息可能有助于评估辐射暴露后潜在的肿瘤诱发情况。
