Blattmann H, Coray A, Pedroni E, Greiner R
Department of Radiation Medicine, PSI - Paul Scherrer Institute, Villigen, Switzerland.
Strahlenther Onkol. 1990 Jan;166(1):45-8.
Protons have a long tradition in precision treatment of lesions of limited size at limited depth. Recently interest has developed in hospital based proton therapy accelerators, able to treat deep seated tumors. Heavy charged particles, and especially protons, are particularly suited to treat well localized tumors. Protons can be collimated as precisely as photons, but in addition have a well defined range. Protons are therefore predestinated for conformation radiotherapy also for larger target volumes. At the Swiss Institute for Nuclear Research a computer optimized treatment planning system has been developed for pion radiotherapy. The principle of this dynamic treatment technique can be adapted for proton therapy. It could prove to be a valid alternative to passive scattering for proton treatment especially of large irregularly shaped volumes. Dose calculations have been performed for specific cases using a 250 MeV pencil beam. The dose distributions and dose volume histograms have been compared with pion therapy. A horizontal experimental beam line, using a degraded 590 MeV proton beam of the PSI ring cyclotron, is set up to verify calculations in phantoms.
质子在精确治疗有限大小、有限深度的病变方面有着悠久的历史。最近,人们对基于医院的质子治疗加速器产生了兴趣,这种加速器能够治疗深部肿瘤。重带电粒子,尤其是质子,特别适合治疗定位良好的肿瘤。质子可以像光子一样精确准直,但除此之外,它还有明确的射程。因此,质子也注定适用于较大靶区体积的适形放射治疗。在瑞士核研究所,已经开发出一种用于π介子放射治疗的计算机优化治疗计划系统。这种动态治疗技术的原理可以应用于质子治疗。对于质子治疗,尤其是大的不规则形状体积的治疗,它可能被证明是被动散射的一种有效替代方法。已经使用250兆电子伏特笔形束对特定病例进行了剂量计算。将剂量分布和剂量体积直方图与π介子治疗进行了比较。利用保罗·谢尔研究所环形回旋加速器的590兆电子伏特降能质子束建立了一条水平实验束线,以验证模型中的计算结果。