Egger-Adam Diane, Katanaev Vladimir L
Department of Biology, University Konstanz, P.O. Box 643, 78457 Konstanz, Germany.
Front Biosci. 2008 May 1;13:4740-55. doi: 10.2741/3036.
Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.
卷曲蛋白（Frizzled）家族受体在动物发育过程中传导重要信号，从海绵动物到人类都保守存在。卷曲蛋白受体属于G蛋白偶联受体（GPCRs）超家族，但直到最近，它们在信号传导方面都被认为不依赖G蛋白。在本文中，我们综述了大量知识，这些知识证明了三聚体G蛋白在脊椎动物和低等动物的卷曲蛋白信号转导中的功能。我们还讨论了卷曲蛋白受体与G蛋白偶联受体的其他结构和功能相似性。
