Department of Cell and Molecular Biology, School of Biology, College of Sciences, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
Iran Biomed J. 2020 Sep;24(5):269-80. doi: 10.29252/ibj.24.5.264. Epub 2020 Apr 29.
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseases, including cancers, neurodegenerative disorders, skin and bone diseases, and heart deficiencies. Therefore, Wnt/β-Catenin signal transduction is a potential clinical target for the treatment of not only human cancers but also some other human chronic diseases. Here, some recent results including those from my laboratory highlighting the role of Wnt/β-Catenin signal transduction in human cancers will be reviewed. After a brief overview on canonical Wnt signaling and introducing some critical β-Catenin/T-cell factor-target genes, the interaction of canonical Wnt signaling with some common human cancers will be discussed. In the end, the different segments of the aforesaid signaling pathway, which have been considered as targets for clinical purposes, will be scrutinized.
精确调控信号转导通路对于正常动物发育以及维持成年个体的细胞和组织内稳态至关重要。Wnt/Frizzled 介导的信号转导包括经典和非经典信号转导通路。经典 Wnt 信号（或 Wnt/β-连环蛋白信号转导）的上调或下调可导致多种人类疾病，包括癌症、神经退行性疾病、皮肤和骨骼疾病以及心脏缺陷。因此，Wnt/β-连环蛋白信号转导是治疗人类癌症和其他一些人类慢性疾病的潜在临床靶点。在这里，将回顾一些最近的研究结果，包括我实验室的研究结果，这些结果强调了 Wnt/β-连环蛋白信号转导在人类癌症中的作用。在简要概述经典 Wnt 信号后，引入一些关键的β-连环蛋白/T 细胞因子靶基因，将讨论经典 Wnt 信号与一些常见的人类癌症的相互作用。最后，将仔细研究上述信号通路的不同片段，这些片段被认为是临床应用的靶点。
