白细胞介素-21在自身免疫性疾病发病机制中的调节能力。
The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease.
作者信息
Vogelzang Alexis, King Cecile
机构信息
Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.
出版信息
Front Biosci. 2008 May 1;13:5304-15. doi: 10.2741/3082.
In this review, we discuss recent progress from studies on the biology of IL-21 and the role of this cytokine in the pathogenesis of autoimmunity. Recent studies have demonstrated that IL-21 plays an important and non-redundant role in a number of autoimmune animal models indicating that IL-21 could be a common modulator of the adaptive immune response towards self-tissue constituents in diseases such as systemic lupus erythematosus, models of rheumatoid arthritis, multiple sclerosis and type-1 diabetes. Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases.
在本综述中，我们讨论了白细胞介素-21生物学研究的最新进展以及这种细胞因子在自身免疫发病机制中的作用。最近的研究表明，白细胞介素-21在多种自身免疫动物模型中发挥着重要且不可替代的作用，这表明白细胞介素-21可能是系统性红斑狼疮、类风湿关节炎模型、多发性硬化症和1型糖尿病等疾病中针对自身组织成分的适应性免疫反应的常见调节因子。此外，关于白细胞介素-21在人类自身免疫性疾病中的产生及其在体外对人类细胞的作用的研究，正在揭示白细胞介素-21加剧决定自身免疫性疾病进程的细胞过程的潜力。
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