Saleh Christian, Okun Michael Scott
Department of Neurology, Bichat University Hospital, 46 rue Henri Huchard, 75018 Paris, France.
Front Biosci. 2008 May 1;13:5708-31. doi: 10.2741/3111.
This paper aims to provide an overview of factors that may contribute to cognitive and mood alterations following DBS (and lesion therapy). A PubMed search based on studies in the English-language was undertaken, and included all publications on the topics of mood and surgery for movement disorders. Information was collected on pre-operative and post-operative characteristics of each study, and study methodology was examined. One-hundred and forty published articles were selected and reviewed for mood and behavior changes following neurosurgery for movement disorders. There were a variety of mood and cognitive changes associated with DBS (and lesion therapy). These alterations of behavior and cognition were seen in all targets but not frequently reported with thalamic DBS. However methodological limitations, small sample sizes, lack of control groups, and the heterogeneity of data reported underscore why interpretation and comparison of limbic effects of DBS remains challenging. The collection and reporting of more standardized minimal data sets will allow for future comparisons, and improve the power required to answer many of the questions raised in this review.
本文旨在概述可能导致脑深部电刺激术（和毁损疗法）后认知及情绪改变的因素。我们基于英文研究在PubMed上进行了检索，纳入了所有关于运动障碍的情绪与手术主题的出版物。收集了每项研究的术前和术后特征信息，并对研究方法进行了审查。我们挑选并审阅了140篇已发表的关于运动障碍神经外科手术后情绪和行为变化的文章。与脑深部电刺激术（和毁损疗法）相关的情绪和认知变化多种多样。这些行为和认知改变在所有靶点均有出现，但丘脑脑深部电刺激术较少报告此类情况。然而，方法学上的局限性、样本量小、缺乏对照组以及所报告数据的异质性，都凸显了为何对脑深部电刺激术边缘系统效应的解释和比较仍具有挑战性。收集和报告更标准化的最小数据集将便于未来进行比较，并提高回答本综述中提出的许多问题所需的效力。
