J Clin Invest. 2013 Nov;123(11):4546-56. doi: 10.1172/JCI68341. Epub 2013 Nov 1.
Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened patients with specific treatment-resistant neuropsychiatric diseases. Some neuropsychiatric conditions, such as Parkinson disease, have available and reasonable guideline and efficacy data, while other conditions, such as major depressive disorder and Tourette syndrome, have more limited, but promising results. This review summarizes both the efficacy and the neuroanatomical targets for DBS in four common neuropsychiatric conditions: Parkinson disease, Tourette syndrome, major depressive disorder, and obsessive-compulsive disorder. Based on emerging new research, we summarize novel approaches to optimization of stimulation for each neuropsychiatric disease and we review the potential positive and negative effects that may be observed following DBS. Finally, we summarize the likely future innovations in the field of electrical neural-network modulation.
脑深部电刺激（DBS）是一种新兴的介入治疗方法，适用于经过精心筛选的特定治疗抵抗性神经精神疾病患者。一些神经精神疾病，如帕金森病，有可用的和合理的指南和疗效数据，而其他疾病，如重度抑郁症和妥瑞氏症，结果则更为有限，但有希望。这篇综述总结了 DBS 在四种常见神经精神疾病中的疗效和神经解剖靶点：帕金森病、妥瑞氏症、重度抑郁症和强迫症。基于新兴的新研究，我们总结了针对每种神经精神疾病优化刺激的新方法，并回顾了 DBS 后可能观察到的潜在积极和消极影响。最后，我们总结了电神经网络调节领域的未来创新。
