Yamanaka Tomoyuki, Ohno Shigeo
Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama 351-0198, Japan.
Front Biosci. 2008 May 1;13:6693-707. doi: 10.2741/3182.
Genetic studies in Drosophila have revealed that three tumor suppressors, Discs large (Dlg), Scribble (Scrib) and Lethal giant larvae (Lgl), which localize to the basolateral region of epithelial cells, cooperatively regulate cell polarity, junction formation and cell growth in epithelial cells. Subsequent studies in Drosophila, vertebrates and C. elegans have shown the evolutionary conservation of some of their functions in epithelial cells. Also, these studies revealed the importance of antagonistic interactions between these tumor suppressors and apical polarity regulators such as Crumbs and aPKC for the establishment of apical-basal polarity with organized cell-cell junctions and regulation of cell growth in epithelial cells.
果蝇的遗传学研究表明，三种肿瘤抑制因子，即定位在上皮细胞基底外侧区域的盘大蛋白（Dlg）、scribble（Scrib）和致死性巨幼虫蛋白（Lgl），协同调节上皮细胞中的细胞极性、连接形成和细胞生长。随后在果蝇、脊椎动物和秀丽隐杆线虫中的研究表明，它们在某些上皮细胞功能上具有进化保守性。此外，这些研究还揭示了这些肿瘤抑制因子与顶端极性调节因子（如Crumb和非典型蛋白激酶C（aPKC））之间的拮抗相互作用对于建立具有有序细胞间连接的顶端-基底极性以及调节上皮细胞生长的重要性。
