Scotet Emmanuel, Nedellec Steven, Devilder Marie-Claire, Allain Sophie, Bonneville Marc
INSERM U892, Departement de Recherche en Cancerologie Nantes-Angers, Nantes, France.
Front Biosci. 2008 May 1;13:6872-85. doi: 10.2741/3195.
Like Natural Killer cells, gammadelta T cells and Natural Killer T cells display several innate-like features that confer them a broad reactivity against tumors and pathogens. By recognizing stress-induced conserved antigens upregulated a wide array of physiopathological contexts, these lymphoid subsets develop strong and early responses to a broad set of targets. One of the most exciting roles possibly played in vivo by non-conventional T lymphocytes, which exhibit a biased natural memory phenotype, is active regulation of adaptive immune responses through interactions with antigen presenting cells (APCs), such as dendritic cells. Here we will review recent studies reporting functional interactions between gammadelta T cells and APC and a possible involvement of these lymphocytes in bridging innate and adaptative immunity along infections and tumor development. Our discussion will focus on human gammadelta T cells and more specifically on Vgamma9Vdelta2 T cells, a major subset found in human peripheral blood.
与自然杀伤细胞一样，γδT细胞和自然杀伤T细胞具有若干类先天性特征，使其对肿瘤和病原体具有广泛的反应性。通过识别在多种生理病理情况下上调的应激诱导保守抗原，这些淋巴细胞亚群对多种靶标产生强烈而早期的反应。具有偏向性自然记忆表型的非常规T淋巴细胞在体内可能发挥的最令人兴奋的作用之一，是通过与抗原呈递细胞（如树突状细胞）相互作用来积极调节适应性免疫反应。在此，我们将综述近期报道γδT细胞与抗原呈递细胞之间功能相互作用的研究，以及这些淋巴细胞在感染和肿瘤发展过程中可能参与连接先天性免疫和适应性免疫的情况。我们的讨论将聚焦于人类γδT细胞，更具体地说是Vγ9Vδ2 T细胞，这是人类外周血中发现的一个主要亚群。
