Grases Felix, Sanchis Pilar, Perello Joan, Isern Bernat, Prieto Rafel M, Fernandez-Palomeque Carlos, Saus Carles
Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research, University of Balearic Islands, Palma de Mallorca, Spain.
Front Biosci. 2008 May 1;13:7115-22. doi: 10.2741/3214.
The aim of this research was to evaluate the effect of dietary phytate on cardiovascular calcification in rats during aging. Male Wistar rats (10 weeks old) were randomly assigned to four diet groups. The control group was fed with a balanced diet (UAR-A04) containing phytate. The AIN group was fed a purified diet (AIN-76A) with an undetectable level of phytate. The PHY group was fed with a purified diet (AIN-76A) enriched with phytate (phytin, as the calcium magnesium salt). The MOD group was fed with the AIN-76A diet (phytate undetectable) enriched with MgO, inositol and CaHPO4. At 76 weeks of age all rats were sacrificed, and the aortas, hearts, kidneys, livers and femurs were removed for chemical analysis. The most significant differences were found in the aorta calcium content. Phytate-treated rats (the control and PHY groups) had significantly lower levels of calcium in the aorta compared to nonphytate-treated rats (AIN and MOD groups). The present study demonstrated that dietary phytate treatment significantly reduced age-related aorta calcification.
本研究的目的是评估膳食植酸盐对衰老过程中大鼠心血管钙化的影响。将雄性Wistar大鼠（10周龄）随机分为四个饮食组。对照组喂食含有植酸盐的均衡饮食（UAR-A04）。AIN组喂食植酸盐含量不可检测的纯化饮食（AIN-76A）。PHY组喂食富含植酸盐（肌醇六磷酸钙镁盐形式的植酸）的纯化饮食（AIN-76A）。MOD组喂食富含氧化镁、肌醇和磷酸氢钙的AIN-76A饮食（植酸盐不可检测）。在76周龄时，处死所有大鼠，并取出主动脉、心脏、肾脏、肝脏和股骨进行化学分析。在主动脉钙含量方面发现了最显著的差异。与未用植酸盐处理的大鼠（AIN组和MOD组）相比，用植酸盐处理的大鼠（对照组和PHY组）主动脉中的钙水平显著降低。本研究表明，膳食植酸盐处理可显著降低与年龄相关的主动脉钙化。
