Pires Sónia M G, Reis Rita Silva, Cardoso Susana M, Pezzani Raffaele, Paredes-Osses Esteban, Seilkhan Ainur, Ydyrys Alibek, Martorell Miquel, Sönmez Gürer Eda, Setzer William N, Abdull Razis Ahmad Faizal, Modu Babagana, Calina Daniela, Sharifi-Rad Javad
LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
Phytotherapy Lab (PhT-Lab), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy.
Front Chem. 2023 Apr 14;11:1174109. doi: 10.3389/fchem.2023.1174109. eCollection 2023.
Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%-80% of total phosphorus. Because phytate is a polyanionic molecule, it can chelate positively charged cations such as calcium, iron, and zinc. Due to its prevalence in vegetal tissues and the fact that people consume plants, phytate was first considered a potential health benefit. This updated review aims to summarize the current data on the results of clinical trials of phytates on human health, highlighting both beneficial and undesirable effects. To obtain these updated data, published papers in electronic databases such as PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, and Scopus were searched. Study results have shown that phytate can have beneficial health effects such as antioxidant, anticancer potential and reduction of pathological calcifications in blood vessels and organs; but also, negative effects by reducing the absorption of minerals important for maintaining the homeostasis of the human body. According to these recent results derived from recent clinical studies, phytates may be a potential natural source for health benefits. To improve clinical efficacy and human health benefits, further dose-response studies are needed to determine effective therapeutic doses and potential interactions with conventional drugs.
植酸盐是植物在陆地生态系统中产生的一种有机磷化合物。在植物饲料中，植酸及其盐形式（即植酸盐）占总磷的60%-80%。由于植酸盐是一种多阴离子分子，它可以螯合带正电荷的阳离子，如钙、铁和锌。鉴于其在植物组织中的普遍性以及人们食用植物这一事实，植酸盐最初被认为对健康有潜在益处。这篇更新的综述旨在总结目前关于植酸盐对人类健康临床试验结果的数据，突出其有益和不良影响。为获取这些更新的数据，检索了电子数据库（如PubMed/MedLine、TRIP数据库、Wiley、谷歌学术、百度和Scopus）中已发表的论文。研究结果表明，植酸盐可产生有益的健康影响，如抗氧化、抗癌潜力以及减少血管和器官中的病理性钙化；但同时也有负面影响，即降低对维持人体稳态至关重要的矿物质的吸收。根据近期临床研究得出的这些最新结果，植酸盐可能是一种潜在的有益健康的天然来源。为提高临床疗效和对人类健康的益处，需要进一步开展剂量反应研究，以确定有效的治疗剂量以及与传统药物的潜在相互作用。
