Green tea and PUMA: a deadly combination?
作者信息
Dudgeon Crissy, Yu Jian
机构信息
University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Cancer Biol Ther. 2008 Jun;7(6):909-10. doi: 10.4161/cbt.7.6.6317. Epub 2008 May 21.
Abstract
摘要
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The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines.
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Inhibition of intestinal tumorigenesis in Apc(min/+) mice by green tea polyphenols (polyphenon E) and individual catechins.
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Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model.
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