Shankar Sharmila, Ganapathy Suthakar, Srivastava Rakesh K
Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas 75703, USA.
Front Biosci. 2007 Sep 1;12:4881-99. doi: 10.2741/2435.
Multiple lines of evidence, mostly from population-based studies, suggest that green tea consumption is associated with reduced risk of several human malignancies such as cancer and diabetes. Epigallocatechin-3-gallate (EGCG), a major polyphenol found in green tea, is a widely studied chemopreventive agent with potential anticancer activity. Green tea polyphenols inhibit angiogenesis and metastasis, and induce growth arrest and apoptosis through regulation of multiple signaling pathways. Specifically, EGCG regulates expression of VEGF, matrix metalloproteinases, uPA, IGF-1, EGFR, cell cycle regulatory proteins and inhibits NFk B, PI3-K/Akt, Ras/Raf/MAPK and AP-1 signaling pathways, thereby causing strong cancer chemopreventive effects. This review discusses the molecular mechanisms of green tea polyphenols and their therapeutic implications in cancer.
多项证据（大多来自基于人群的研究）表明，饮用绿茶与降低患多种人类恶性肿瘤（如癌症和糖尿病）的风险有关。表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中发现的一种主要多酚，是一种经过广泛研究的具有潜在抗癌活性的化学预防剂。绿茶多酚可抑制血管生成和转移，并通过调节多种信号通路诱导生长停滞和细胞凋亡。具体而言，EGCG调节血管内皮生长因子（VEGF）、基质金属蛋白酶、尿激酶型纤溶酶原激活剂（uPA）、胰岛素样生长因子-1（IGF-1）、表皮生长因子受体（EGFR）、细胞周期调节蛋白的表达，并抑制核因子κB（NFκB）、磷脂酰肌醇-3-激酶/蛋白激酶B（PI3-K/Akt）、Ras/丝裂原活化蛋白激酶激酶/丝裂原活化蛋白激酶（Ras/Raf/MAPK）和激活蛋白-1（AP-1）信号通路，从而产生强大的癌症化学预防作用。本文综述了绿茶多酚的分子机制及其在癌症治疗中的意义。
