Miniello Stefano, Jirillo Emilio, Cristallo Graziana, Marzaioli Rinaldo, Lorusso Curzio, Lippolis Agostino, Giove Eleonora, Nacchiero Michele
Sezione di Chirurgia d'Urgenza e del Trauma, Dipartimento per le Applicazioni in Chirurgia delle Tecnologie Innovative, Università degli Studi di Bari, Facoltà di Medicina e Chirurgia, Bari.
Ann Ital Chir. 2007 Nov-Dec;78(6):499-502.
The Authors, studying the condition of immunodepression observed in patients who underwent splenectomy for traumatic lesion, noticed that a significant part of them complained of allergic symptoms. These seemed to appear only in subjects whose Th2 lymphocytes functionality was preserved--as witnessed by normal or increased IL-4 serum level--showing an increased level of IgE too, thus confirming the role of Th2 lymphocytes in stimulating IgE synthesis. On the contrary splenectomized patients with functional harm of the Th2 lymphocytes--proved by low IL-4 serum level--did not show increase of haematic IgE level nor allergic manifestations. The Authors stress that, despite the small numerical of the series not allowing definitive judgment, preliminary data are suggestive for an hypothesis--reported below--that needs further confirmation. The ablation of the spleen, organ devoted to remove from the blood antigens--many of these potentially allergic factors--, allows the prolonged persistence of such sensitizing agents, thus promoting the onset of allergic manifestations in splenectomized patients whose Th2 lymphocytes function is preserved.
作者们在研究因创伤性损伤而接受脾切除术的患者中观察到的免疫抑制状况时，注意到其中很大一部分患者抱怨有过敏症状。这些症状似乎仅出现在Th2淋巴细胞功能得以保留的受试者中——血清IL - 4水平正常或升高可证明这一点——同时这些受试者的IgE水平也有所升高，从而证实了Th2淋巴细胞在刺激IgE合成中的作用。相反，Th2淋巴细胞功能受损的脾切除患者——血清IL - 4水平低可证明——其血液中IgE水平并未升高，也没有出现过敏表现。作者们强调，尽管该系列病例数量较少，无法做出确定性判断，但初步数据提示了如下一种假说，该假说需要进一步证实。脾脏作为负责从血液中清除抗原——其中许多是潜在的过敏因素——的器官，其切除使得这些致敏剂能够长期存在，从而促使Th2淋巴细胞功能得以保留的脾切除患者出现过敏表现。
