Balsalobre B, Enguidanos M J, Hernández-Godoy J, Planelles D, Mir A
Department of Microbiology, University of Valencia, Spain.
J Investig Allergol Clin Immunol. 1993 Sep-Oct;3(5):268-70.
In addition to allergic diseases, there are other disorders that can be accompanied by increased levels of total serum IgE. It has been demonstrated that splenectomy can alter the serum concentrations of other immunoglobulins. The aim of this study was to examine the concentrations of total IgE in the serum of patients splenectomized as a result of abdominal trauma but with no associated disease. Our results show that the average concentrations in the serum of patients were significantly higher that in the control group. Furthermore, in a large number of patients, the concentrations were above the normal limit set for the nonatopic Spanish population. These results suggest that splenectomy can alter the regulation of IgE concentrations. Since total IgE is usually determined for diagnostic purposes, it is useful to be aware of this anomaly when dealing with splenectomized patients in order to interpret correctly the laboratory analyses.
除了过敏性疾病外，还有其他疾病可能伴有血清总IgE水平升高。已经证明脾切除术可改变其他免疫球蛋白的血清浓度。本研究的目的是检测因腹部创伤行脾切除术但无相关疾病患者血清中的总IgE浓度。我们的结果显示，患者血清中的平均浓度显著高于对照组。此外，在大量患者中，浓度高于为非特应性西班牙人群设定的正常上限。这些结果表明脾切除术可改变IgE浓度的调节。由于通常为诊断目的测定总IgE，因此在处理脾切除患者时了解这一异常情况有助于正确解读实验室分析结果。
