肿瘤坏死因子受体和免疫球蛋白超家族成员形成一个控制树突状细胞稳态的整合信号回路。
The TNF receptor and Ig superfamily members form an integrated signaling circuit controlling dendritic cell homeostasis.
作者信息
De Trez Carl, Ware Carl F
机构信息
Laboratory of Parasitology, Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Bruxelles, Belgium.
出版信息
Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):277-84. doi: 10.1016/j.cytogfr.2008.04.013. Epub 2008 Jun 3.
Abstract
Dendritic cells (DC) constitute the most potent antigen presenting cells of the immune system, playing a key role bridging innate and adaptive immune responses. Specialized DC subsets differ depending on their origin, tissue location and the influence of trophic factors, the latter remain to be fully understood. Myeloid-associated lymphotoxin-beta receptor (LTbetaR) signaling is required for the local proliferation of lymphoid tissue DC. This review focuses on the LTbetaR signaling cascade as a crucial positive trophic signal in the homeostasis of DC subsets. The noncanonical coreceptor pathway comprised of the immunoglobulin (Ig) superfamily member, B and T lymphocyte attenuator (BTLA) and TNFR superfamily member, herpesvirus entry mediator (HVEM) counter regulates the trophic signaling by LTbetaR. Together both pathways form an integrated signaling circuit achieving homeostasis of DC subsets.
摘要
树突状细胞（DC）是免疫系统中最强大的抗原呈递细胞，在连接固有免疫和适应性免疫反应中起关键作用。专门的DC亚群因其起源、组织位置和营养因子的影响而有所不同，后者仍有待充分了解。髓样相关淋巴毒素β受体（LTbetaR）信号传导是淋巴组织DC局部增殖所必需的。本综述重点关注LTbetaR信号级联作为DC亚群稳态中至关重要的正向营养信号。由免疫球蛋白（Ig）超家族成员、B和T淋巴细胞衰减器（BTLA）以及肿瘤坏死因子受体超家族成员、疱疹病毒进入介质（HVEM）组成的非经典共受体途径对LTbetaR的营养信号传导起反向调节作用。这两条途径共同形成一个整合的信号回路，实现DC亚群的稳态。
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