Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901N. Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Opin Immunol. 2013 Apr;25(2):222-9. doi: 10.1016/j.coi.2013.01.001. Epub 2013 Jan 20.
Accumulating evidence indicates that Lymphotoxin (LT)-β related cytokines directly contribute to the phenotype of cancer cells and alter the tumor microenvironment. Lymphotoxins are part of a cytokine network well known in controlling the development and homeostasis of secondary lymphoid organs. In the adult, the LT network takes on the responsibility of generating inflammatory microenvironments that control innate and adaptive immune responses involved in host defense. This review provides a perspective of the emerging evidence implicating the LT Network in the development and progression of various cancers including lymphoma. Redirecting the LT Network to alter tumor microenvironments may provide a specific approach to therapeutically target tumor-permissive microenvironments and cancer progression.
越来越多的证据表明，淋巴毒素 (LT)-β 相关细胞因子直接促成癌细胞的表型，并改变肿瘤微环境。淋巴毒素是控制次级淋巴器官发育和稳态的细胞因子网络的一部分。在成人中，LT 网络承担着产生炎症微环境的责任，这种微环境控制着参与宿主防御的固有和适应性免疫反应。本综述提供了一个新的视角，即 LT 网络参与各种癌症（包括淋巴瘤）的发展和进展。改变 LT 网络以改变肿瘤微环境可能为治疗性靶向肿瘤允许的微环境和癌症进展提供一种特定的方法。
