Kudo M, Vera D R, Stadalnik R C, Trudeau W L, Ikekubo K, Todo A
Department of Medicine, Kobe City General Hospital, Japan.
Nihon Shokakibyo Gakkai Zasshi. 1991 Jan;88(1):40-50.
[Tc-99m] Galactosyl-neoglycoalbumin (TcNGA) is a synthetic radiolabeled ligand specific to the hepatocyte receptor, hepatic binding protein (HBP), a specific receptor to serum asialoglycoprotein. A TcNGA study was performed on 34 humans: normal volunteers (7) chronic hepatitis (6), hepatic cirrhosis (8), and hepatocellular carcinoma superimposed on cirrhosis (13). Heart and liver time activity curves were obtained following intravenous injection of TcNGA (5 mCi, 1.82 x 10(-9) mol/kg). HBP concentration ([HBP]) was calculated by curve-fitting techniques using the nonlinear three compartment model, which includes biomolecular reaction between HBP and TcNGA. [HBP] values were compared with conventional liver function tests. [HBP] had a good correlation with prothrombin time (n = 34, r = 0.694, p = 0.0001) thrombotest (n = 34, r = 0.692, p = 0.0001), hepaplastin test (n = 26, r = 0.787, p = 0.0001), albumin (n = 34, r = 0.712, p = 0.0001), cholinesterase (n = 34, r = 0.801, p = 0.0001), ICGR15 (n = 33, r = 0.761, p = 0.0001), KICG (n = 30, r = 0.709, p = 0.0001), ICG Rmax (n = 12, r = 0.735, p = 0.0064) and Child-Turcotte classification score (n = 34, r = 0.819, p = 0.0001). We concluded that excellent correlations of [HBP] to conventional liver function tests suggest that in vivo receptor measurement via TcNGA kinetic analysis is a sensitive and promising method in the estimation of hepatic functional reserve in patients with chronic liver disease.
[锝-99m]半乳糖基新糖白蛋白（TcNGA）是一种合成的放射性标记配体，对肝细胞受体——肝结合蛋白（HBP）具有特异性，HBP是血清去唾液酸糖蛋白的一种特异性受体。对34名受试者进行了TcNGA研究：正常志愿者（7名）、慢性肝炎患者（6名）、肝硬化患者（8名）以及肝硬化合并肝细胞癌患者（13名）。静脉注射TcNGA（5毫居里，1.82×10⁻⁹摩尔/千克）后，获得心脏和肝脏的时间-活性曲线。使用非线性三室模型通过曲线拟合技术计算HBP浓度（[HBP]），该模型包括HBP与TcNGA之间的生物分子反应。将[HBP]值与传统肝功能检查结果进行比较。[HBP]与凝血酶原时间（n = 34，r = 0.694，p = 0.0001）、血栓弹力图（n = 34，r = 0.692，p = 0.0001）、肝促凝血酶原激酶试验（n = 26，r = 0.787，p = 0.0001）、白蛋白（n = 34，r = 0.712，p = 0.0001）、胆碱酯酶（n = 34，r = 0.801，p = 0.0001）、ICGR15（n = 33，r = 0.761，p = 0.0001）、KICG（n = 30，r = 0.709，p = 0.0001）、ICG Rmax（n = 12，r = 0.735，p = 0.0064）以及Child-Turcotte分类评分（n = 34，r = 0.819，p = 0.0001）均具有良好的相关性。我们得出结论，[HBP]与传统肝功能检查结果具有良好的相关性，这表明通过TcNGA动力学分析进行体内受体测量是评估慢性肝病患者肝功能储备的一种敏感且有前景的方法。
