The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis.
作者信息
Chang Monica, Saiki Randall K, Cantanese Joseph J, Lew David, van der Helm-van Mil Annette H M, Toes Rene E M, Huizinga Thomas W J, Ardlie Kristin G, Criswell Lindsey A, Seldin Michael F, Amos Christopher I, Kastner Daniel L, Gregersen Peter K, Schrodi Steven J, Begovich Ann B
机构信息
Celera, Alameda, CA, USA.
出版信息
Arthritis Rheum. 2008 Jun;58(6):1877-81. doi: 10.1002/art.23492.
Abstract
摘要
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The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis.白细胞介素12B（IL12B）和白细胞介素23受体（IL23R）中与炎症性疾病相关的变异与类风湿性关节炎无关。
Arthritis Rheum. 2008 Jun;58(6):1877-81. doi: 10.1002/art.23492.
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The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis.多发性硬化症中与自身免疫性疾病相关的白细胞介素12B和白细胞介素23受体基因多态性
Hum Immunol. 2007 Nov;68(11):934-7. doi: 10.1016/j.humimm.2007.09.005. Epub 2007 Oct 8.
2
Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort.在英国一个队列中，IL-12β和IL-23R基因的多态性与早发性银屑病相关。
J Invest Dermatol. 2008 May;128(5):1325-7. doi: 10.1038/sj.jid.5701140. Epub 2007 Nov 22.
3
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.对四种疾病中的14500个非同义单核苷酸多态性进行关联扫描，发现了自身免疫性变异。
Nat Genet. 2007 Nov;39(11):1329-37. doi: 10.1038/ng.2007.17. Epub 2007 Oct 21.
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A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.一种候选基因方法将TRAF1/C5区域鉴定为类风湿性关节炎的一个风险因素。
PLoS Med. 2007 Sep;4(9):e278. doi: 10.1371/journal.pmed.0040278.
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STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.信号转导和转录激活因子4与类风湿性关节炎及系统性红斑狼疮的风险
N Engl J Med. 2007 Sep 6;357(10):977-86. doi: 10.1056/NEJMoa073003.
6
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.全基因组研究：TRAF1-C5作为类风湿关节炎的一个风险基因座
N Engl J Med. 2007 Sep 20;357(12):1199-209. doi: 10.1056/NEJMoa073491. Epub 2007 Sep 5.
7
Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.西班牙类风湿性关节炎队列中IL23R基因的研究。
Hum Immunol. 2007 Aug;68(8):681-4. doi: 10.1016/j.humimm.2007.05.008. Epub 2007 Jun 19.
8
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.白细胞介素-23受体（IL23R）及其配体（IL12B）基因中的序列变异赋予对银屑病的保护作用。
Hum Genet. 2007 Sep;122(2):201-6. doi: 10.1007/s00439-007-0397-0. Epub 2007 Jun 22.
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.对14000例七种常见疾病患者及3000例共享对照进行全基因组关联研究。
Nature. 2007 Jun 7;447(7145):661-78. doi: 10.1038/nature05911.
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.自噬基因IRGM及多个其他复制位点的序列变异会导致克罗恩病易感性。
Nat Genet. 2007 Jul;39(7):830-2. doi: 10.1038/ng2061. Epub 2007 Jun 6.
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