白细胞介素12B基因多态性与类风湿关节炎易感性：数据综合分析
Interleukin 12B gene polymorphisms and susceptibility to rheumatoid arthritis: a data synthesis.
作者信息
Yang Xiaoqin, Xiao Fei, Luo Dan, Wang Guiping, Liang Shuang
机构信息
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Department of Pharmacy, College of Health sciences, Guangzhou Medical University, Guangzhou, China.
出版信息
Clin Rheumatol. 2017 Feb;36(2):299-307. doi: 10.1007/s10067-016-3327-5. Epub 2016 Jun 16.
The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on articles published before 28 February 2016. Then odds ratio (OR) with 95 % confidence interval (CI) was used to quantify the strength of association for homozygote, heterozygote, dominant, and recessive genetic models. Nine articles with a total of 17 case-control studies (12 for IL-12B rs3212227 polymorphism and 5 for IL-12B rs6887695 polymorphism) met our inclusion criteria. The pooled results demonstrated that IL-12B rs3212227 (homozygote model: OR = 0.96, 95 % CI = 0.81-1.15; heterozygote model: OR = 1.07, 95 % CI = 0.93-1.23; dominant model: OR = 1.05, 95 % CI = 0.91-1.20; recessive model: OR = 0.93, 95 % CI = 0.79-1.10) and rs6887695 (homozygote model: OR = 1.01, 95 % CI = 0.84-1.21; heterozygote model: OR = 1.14, 95 % CI = 0.86-1.51; dominant model: OR = 1.14, 95 % CI = 0.87-1.48; recessive model: OR = 1.01, 95 % CI = 0.85-1.21) polymorphisms may not be associated with RA risk. Our meta-analyses demonstrated that IL-12B rs3212227 and rs6887695 polymorphisms do not confer susceptibility to RA.
本研究旨在通过荟萃分析探讨两种常见的白细胞介素12B（IL-12B）基因多态性（rs3212227和rs6887695）与类风湿关节炎（RA）易感性之间的关联。对PubMed、Web of Science、Cochrane图书馆和Embase数据库进行了系统的文献检索，检索截至2016年2月28日发表的文章。然后，采用优势比（OR）及其95%置信区间（CI）来量化纯合子、杂合子、显性和隐性遗传模型的关联强度。共有9篇文章（包含17项病例对照研究，其中12项针对IL-12B rs3212227基因多态性，5项针对IL-12B rs6887695基因多态性）符合纳入标准。汇总结果表明，IL-12B rs3212227（纯合子模型：OR = 0.96，95%CI = 0.81 - 1.15；杂合子模型：OR = 1.07，95%CI = 0.93 - 1.23；显性模型：OR = 1.05，95%CI = 0.91 - 1.20；隐性模型：OR = 0.93，95%CI = 0.79 - 1.10）和rs6887695（纯合子模型：OR = 1.01，95%CI = 0.84 - 1.21；杂合子模型：OR = 1.14，95%CI = 0.86 - 1.51；显性模型：OR = 1.14，95%CI = 0.87 - 1.48；隐性模型：OR = 1.01，95%CI = 0.85 - 1.21）基因多态性可能与RA风险无关。我们的荟萃分析表明，IL-12B rs3212227和rs6887695基因多态性不会使个体易患RA。
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