Trias I, Campo E, Benasco C, Palacin A, Cardesa A
Department of Pathology, Hospital de Bellvitge Princeps d'Espanya, Universidad de Barcelona, Spain.
Pathol Res Pract. 1991 Jan;187(1):44-9. doi: 10.1016/S0344-0338(11)81043-5.
We have examined immunohistochemically the presence of human chorionic gonadotrophin (hCG) in 29 esophageal carcinomas: 24 squamous cell carcinomas, 2 adenocarcinomas, 2 adenoid cystic carcinomas and 1 adenosquamous carcinoma. In hCG-positive tumors, the presence of human placental lactogen (hPL) and pregnancy-specific beta-1 glycoprotein (SP-1) was also assessed. HCG immunoreactive cells were found in 5 squamous cell carcinomas (21%) and in none of 5 non-squamous cell tumors. The hCG positive cells were found in the most infiltrating areas of the tumors where poorly differentiated and pleomorphic cells predominated. The positive tumors were 4 poorly differentiated (31%) and one moderately differentiated carcinoma (12%). Four out of 10 cases (40%) with lymph node metastases had hCG in the primary tumor, whereas only one out of 11 cases (9%) without metastases was hCG positive. HPL and SP-1 were found in two cases. These placental proteins were detected in similar areas than hCG but the number of hPL and SP-1 immunoreactive cells was lower than hCG positive cells. SP-1 was also seen in areas of squamous cell differentiation negative for hCG. None of these two cases showed trophoblastic differentiation.
我们采用免疫组织化学方法检测了29例食管癌中人类绒毛膜促性腺激素（hCG）的存在情况，其中包括24例鳞状细胞癌、2例腺癌、2例腺样囊性癌和1例腺鳞癌。对于hCG阳性的肿瘤，还评估了人胎盘催乳素（hPL）和妊娠特异性β1糖蛋白（SP-1）的存在情况。在5例鳞状细胞癌（21%）中发现了hCG免疫反应性细胞，而5例非鳞状细胞肿瘤中均未发现。hCG阳性细胞出现在肿瘤浸润最严重的区域，这些区域以低分化和多形性细胞为主。阳性肿瘤中有4例为低分化癌（31%）和1例中分化癌（12%）。在10例有淋巴结转移的病例中，有4例（40%）原发肿瘤中有hCG，而在11例无转移的病例中，只有1例（9%）hCG呈阳性。在2例中发现了hPL和SP-1。这些胎盘蛋白在与hCG相似的区域被检测到，但hPL和SP-1免疫反应性细胞的数量低于hCG阳性细胞。在hCG呈阴性的鳞状细胞分化区域也发现了SP-1。这2例均未显示滋养层分化。
