Boucher L D, Yoneda K
Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Hum Pathol. 1995 Nov;26(11):1201-6. doi: 10.1016/0046-8177(95)90194-9.
The authors studied the expression of trophoblastic cell markers in lung carcinomas cells by immunoperoxidase staining using antibodies against three trophoblastic glycoproteins (human chorionic gonadotropin [hCG]; human placental lactogen [hPL]; pregnancy-specific beta 1-glycoprotein [SP-1]). One hundred five tissue sections from 44 lung carcinomas of various histological types were examined for positive staining with three antibodies. Hematoxylin-eosin-stained sections from the same tissue blocks were examined for the presence of tumor giant cells. The aim was to study the relationship between tumor giant cells and the trophoblastic glycoprotein expression in lung carcinomas. Small cell carcinoma (SCC) did not show any positive reaction with all three markers. Squamous cell carcinoma (SQCC) showed positive staining with hCG in 21% of cases, hPL in 28%, and SP-1 in 64%. Adenocarcinoma showed positive staining with hCG in 60% of cases, hPL in 10%, and SP-1 in 80%. Large cell carcinoma (LCC) showed positive staining with hCG in 93% of cases, hPL in 56%, and SP-1 in 93%. The positive reaction did not appear to be restricted to nor associated with the tumor giant cells. It was concluded that these trophoblastic cell markers are expressed in various types of lung carcinomas and that they are not associated with certain histological types or with tumor giant cells.
作者使用针对三种滋养层糖蛋白（人绒毛膜促性腺激素[hCG]；人胎盘催乳素[hPL]；妊娠特异性β1-糖蛋白[SP-1]）的抗体，通过免疫过氧化物酶染色研究了肺癌细胞中滋养层细胞标志物的表达。对来自44例不同组织学类型肺癌的105个组织切片进行了三种抗体的阳性染色检测。对同一组织块的苏木精-伊红染色切片进行肿瘤巨细胞检测。目的是研究肺癌中肿瘤巨细胞与滋养层糖蛋白表达之间的关系。小细胞癌（SCC）对所有三种标志物均未显示任何阳性反应。鳞状细胞癌（SQCC）中，21%的病例hCG呈阳性染色，28%的病例hPL呈阳性染色，64%的病例SP-1呈阳性染色。腺癌中，60%的病例hCG呈阳性染色，10%的病例hPL呈阳性染色，80%的病例SP-1呈阳性染色。大细胞癌（LCC）中，93%的病例hCG呈阳性染色，56%的病例hPL呈阳性染色，93%的病例SP-1呈阳性染色。阳性反应似乎并不局限于肿瘤巨细胞，也与肿瘤巨细胞无关。得出的结论是，这些滋养层细胞标志物在各种类型的肺癌中均有表达，且它们与特定的组织学类型或肿瘤巨细胞无关。
