Anderson B O, Bensard D D, Harken A H
Department of Surgery, University of Colorado Health Sciences Center, Denver 80262.
Surg Gynecol Obstet. 1991 May;172(5):415-24.
PAF has been implicated as a mediator of shock, sepsis and MOF. The results of experimental data demonstrate that PAF induces changes characteristic of endotoxemia and sepsis, including systemic hypotension and diffuse microvascular leakage. These effects are prevented by PAF antagonists. PAF induces many of the characteristic changes of MOF, including functional impairment in the lung, kidney, gastrointestinal tract and heart. PAF antagonists will inhibit these adverse effects. PAF antagonists are now being manufactured by a number of pharmaceutical companies studying the beneficial effects of PAF antagonists in human disease. Data from these studies promise valuable information with significant clinical relevance to the practicing surgeon.
血小板活化因子（PAF）被认为是休克、脓毒症和多器官功能障碍综合征（MOF）的介质。实验数据结果表明，PAF可引发内毒素血症和脓毒症的特征性变化，包括全身性低血压和弥漫性微血管渗漏。这些效应可被PAF拮抗剂阻断。PAF可引发MOF的许多特征性变化，包括肺、肾、胃肠道和心脏的功能损害。PAF拮抗剂可抑制这些不良反应。目前多家制药公司正在生产PAF拮抗剂，并研究其在人类疾病中的有益作用。这些研究的数据有望为执业外科医生提供具有重要临床意义的有价值信息。
