氟喹诺酮类药物对脂多糖诱导的死亡的保护作用。
Protection against lipopolysaccharide-induced death by fluoroquinolones.
作者信息
Khan A A, Slifer T R, Araujo F G, Suzuki Y, Remington J S
机构信息
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301, USA.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3169-73. doi: 10.1128/AAC.44.11.3169-3173.2000.
Abstract
Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100 mg/kg), ciprofloxacin (250 mg/kg), and tosufloxacin (100 mg/kg) protected 75% (P = 0.0001), 25% (P = 0.002), and 50% (P = 0.002), respectively, of mice against death. The fluoroquinolones significantly reduced serum levels of interleukin-6 and tumor necrosis factor alpha in LPS-treated mice. The protective effects of fluoroquinolones in LPS-induced shock in mice may also occur in humans.
摘要
由于氟喹诺酮类药物对经脂多糖（LPS）处理的人单核细胞产生的细胞因子具有免疫调节作用，我们研究了氟喹诺酮类药物对注射致死剂量LPS的小鼠存活率的影响。曲伐沙星（100mg/kg）、环丙沙星（250mg/kg）和妥舒沙星（100mg/kg）分别使75%（P = 0.0001）、25%（P = 0.002）和50%（P = 0.002）的小鼠免于死亡。氟喹诺酮类药物显著降低了LPS处理小鼠的血清白细胞介素-6和肿瘤坏死因子α水平。氟喹诺酮类药物对小鼠LPS诱导休克的保护作用在人类中也可能出现。
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