Hasui Y, Nishi S, Kitada S, Osada Y, Sumiyoshi A
Department of Urology, Miyazaki Medical College, Japan.
Urol Res. 1991;19(1):69-72. doi: 10.1007/BF00294025.
An immunohistochemical analysis using antibodies to cytokeratin, epithelial membrane antigen, alpha-1-antitrypsin, alpha-1-antichymotrypsin and factor XIIIa was performed in four cases of malignant fibrous histiocytoma and five cases of sarcomatoid carcinoma in the urinary tract. All cases of malignant fibrous histiocytoma showed positive staining for factor XIIIa, alpha-1-antitrypsin and alpha-1-antichymotrypsin. No case was positive for factor XIIIa, but one case with sarcomatoid carcinoma stained positive for alpha-1-antitrypsin and alpha-1-antichymotrypsin. All cases showed positive staining for cytokeratin and 4 cases with sarcomatoid carcinoma were positive for epithelial membrane antigen, but no cases with malignant fibrous histiocytoma were positive. Immunohistochemical analysis would thus help to distinguish malignant fibrous histiocytoma from sarcomatoid carcinoma of the urinary tract.
对4例恶性纤维组织细胞瘤和5例泌尿道肉瘤样癌进行了免疫组织化学分析，所用抗体针对细胞角蛋白、上皮膜抗原、α1抗胰蛋白酶、α1抗糜蛋白酶和因子ⅩⅢa。所有恶性纤维组织细胞瘤病例对因子ⅩⅢa、α1抗胰蛋白酶和α1抗糜蛋白酶呈阳性染色。没有肉瘤样癌病例对因子ⅩⅢa呈阳性，但有1例肉瘤样癌对α1抗胰蛋白酶和α1抗糜蛋白酶呈阳性染色。所有病例对细胞角蛋白呈阳性染色，4例肉瘤样癌对上皮膜抗原呈阳性，但恶性纤维组织细胞瘤病例均为阴性。因此，免疫组织化学分析有助于区分泌尿道恶性纤维组织细胞瘤和肉瘤样癌。
