实验性恶性纤维组织细胞瘤中溶菌酶和波形蛋白的免疫组织化学鉴定
Immunohistochemical identification of lysozyme and vimentin in an experimental malignant fibrous histiocytoma.
作者信息
Ribeiro R A, Fonteles M C, Zucoloto S, Bacchi C E
机构信息
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brasil.
出版信息
Braz J Med Biol Res. 1988;21(5):995-7.
The immunoperoxidase avidin-biotin-peroxidase complex method was used to investigate the presence of histiocyte markers such as lysozyme, alpha-1-antitrypsin (A1AT) and alpha-1-anti-chymotrypsin (A1ACT) and of vimentin, a specific marker for mesenchymal differentiation, in a spontaneous and transplantable rat tumor of supposed fibroblastic-histiocytic origin. Positive staining was obtained for lysozyme and vimentin but A1AT and A1ACT were not demonstrable in any of the tumor sections. These results provide evidence for the fibro-histiocytic nature of the tumor studied and suggest its classification as a malignant fibrous histiocytoma (MFH).
采用免疫过氧化物酶抗生物素蛋白-生物素-过氧化物酶复合物法，研究一种推测为成纤维细胞-组织细胞起源的自发性和可移植性大鼠肿瘤中组织细胞标志物（如溶菌酶、α1抗胰蛋白酶（A1AT）和α1抗糜蛋白酶（A1ACT））以及间充质分化的特异性标志物波形蛋白的存在情况。溶菌酶和波形蛋白呈阳性染色，但在任何肿瘤切片中均未检测到A1AT和A1ACT。这些结果为所研究肿瘤的纤维组织细胞性质提供了证据，并提示将其分类为恶性纤维组织细胞瘤（MFH）。
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