顺铂和依托泊苷用于原发性肺癌化疗的疗效与副作用
[The efficacy and side effects of chemotherapy for primary lung cancer with cisplatin and etoposide].
作者信息
Tsutsumi T, Kawakami A, Ozawa Y, Kawaguchi H, Fujii H, Sawano T, Asamoto H
机构信息
Department of Respiratory Medicine, Kyoto National Hospital, Fushimi-ku, Japan.
出版信息
Gan To Kagaku Ryoho. 1991 May;18(6):1003-6.
We treated 34 primary lung cancer patients with chemotherapy of cisplatin and etoposide. There were 2 cases of CR (15%) and 8 cases of PR (61%) out of 13 cases of small cell lung cancer. No case of CR and one case of PR (5%) were obtained out of 21 cases of non-small cell cancer. Side effects were leukopenia, increase of BUN and creatinine, angina pectoris, supraventricular premature contraction, and renal failure. WBC reached nadir on day 15 on average. When we repeated this regimen, we encountered 3 cases of acute myocardial infarction, and it was useful for small cell lung cancer.
我们用顺铂和依托泊苷化疗方案治疗了34例原发性肺癌患者。13例小细胞肺癌患者中，有2例完全缓解（CR，15%），8例部分缓解（PR，61%）。21例非小细胞肺癌患者中无完全缓解病例，有1例部分缓解（5%）。副作用包括白细胞减少、血尿素氮和肌酐升高、心绞痛、室上性早搏和肾衰竭。白细胞平均在第15天降至最低点。当我们重复该方案时，出现了3例急性心肌梗死，该方案对小细胞肺癌有效。
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