Bigos K L, Folan M M, Jones M R, Haas G L, Kroboth F J, Kroboth P D
J Psychiatr Res. 2009 Jan;43(4):442-5. doi: 10.1016/j.jpsychires.2008.04.007. Epub 2008 Jun 2.
Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.
据报道，强迫症（OCD）患者体内包括促肾上腺皮质激素、促肾上腺皮质激素释放激素和皮质醇在内的激素浓度会发生变化。但尚未对强迫症患者的脱氢表雄酮（DHEA）及其硫酸化代谢产物硫酸脱氢表雄酮（DHEA-S）进行评估。我们报告了一名患有强迫症的年轻男性以及15名健康年轻男性的24小时血清DHEA、DHEA-S和皮质醇浓度。强迫症患者体内DHEA和皮质醇的昼夜模式与对照受试者明显不同。强迫症受试者体内的DHEA和DHEA-S浓度显著高于对照受试者。相比之下，强迫症受试者和对照受试者的皮质醇浓度相似。未来需要进行临床研究以评估DHEA和DHEA-S在强迫症中的意义。
