INERIS, Institut National de l'Environnement Industriel et des Risques, Unité de Toxicologie Expérimentale, Parc Alata BP2, 60550 Verneuil-en-Halatte, France.
Ecotoxicol Environ Saf. 2008 Nov;71(3):869-73. doi: 10.1016/j.ecoenv.2008.04.009. Epub 2008 Jun 2.
Sediments usually contain mixtures of trace metals introduced via natural geochemical processes and anthropogenic activities. Kinetics and effects of these metals are strongly dependent both on the composition of the mixture and on the physico-chemical characteristics of the sediment. Relating effects to metal concentration may consequently be advised. However, total accumulation may be a poor predictor of metal toxicity for Chironomus riparius exposed to contaminated field sediments. As an alternative, we proposed to relate effects on Chironomus growth with cytosolic metal accumulation, measured in larvae after a short exposure period. Dose-response relationships were derived for zinc, copper, and cadmium through single-metal exposure data analysed with toxicokinetics and toxicodynamics models. They permitted, on the basis of cytosolic accumulation measures, to predict successfully the effects of mixtures of cadmium, zinc, and copper on the growth of larvae exposed to spiked sediments, as well as to field sediments in which zinc and copper were assumed to be predominant.
沉积物通常包含通过自然地球化学过程和人为活动引入的痕量金属的混合物。这些金属的动力学和效应强烈依赖于混合物的组成和沉积物的物理化学特性。因此，将效应与金属浓度相关联可能是明智的。然而，对于暴露于污染现场沉积物的摇蚊幼虫来说，总积累可能不能很好地预测金属毒性。作为替代方法，我们建议将摇蚊生长的影响与细胞质金属积累相关联，这是在短暴露期后在幼虫中测量的。通过用毒代动力学和毒效动力学模型分析单金属暴露数据，得出了锌、铜和镉的剂量-反应关系。它们基于细胞质积累的测量，成功地预测了添加到沉积物中以及假设锌和铜为主的现场沉积物中混合镉、锌和铜对幼虫生长的影响。
