Abbasian C, Power P
Lambeth Early Onset (LEO) Team, Lambeth Hospital, London, UK; Maudsley NHS Foundation Trust, Reay House, Lambeth Hospital, London, UK.
J Psychopharmacol. 2009 Mar;23(2):214-5. doi: 10.1177/0269881108089591. Epub 2008 May 30.
This is a case report of a 24-year-old African lady, who developed symptoms of tardive dyskinesia (TD) following 9 months of treatment with aripiprazole 15 mg. She has no family history of mental illness, not used illicit substances and has a medical diagnosis of idiopathic hypertension which is well controlled. The patient has an 18-month history of paranoid schizophrenia with three psychotic episodes, one severe enough to warrant admission. Upon discontinuation of aripiprazole and switch to quetiapine, the symptoms of TD disappeared rapidly. A PubMed search revealed one previous case report of aripiprazole and TD. The authors recommend maintaining vigilance regarding all possible side-effects irrespective of the type of antipsychotic being used.
这是一例关于一名24岁非洲女性的病例报告。该女性在服用15毫克阿立哌唑治疗9个月后出现迟发性运动障碍（TD）症状。她没有精神疾病家族史，未使用过非法药物，患有特发性高血压，病情控制良好。该患者有18个月的偏执型精神分裂症病史，出现过三次精神病发作，其中一次严重到需要住院治疗。停用阿立哌唑并换用喹硫平后，TD症状迅速消失。一项PubMed搜索显示之前有一篇关于阿立哌唑与TD的病例报告。作者建议，无论使用何种抗精神病药物，都要对所有可能的副作用保持警惕。
