Visser P J, Verhey F R J, Boada M, Bullock R, De Deyn P P, Frisoni G B, Frolich L, Hampel H, Jolles J, Jones R, Minthon L, Nobili F, Olde Rikkert M, Ousset P-J, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Touchon J, Tsolaki M, Vellas B, Wahlund L-O, Wilcock G, Winblad B
Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands.
Neuroepidemiology. 2008;30(4):254-65. doi: 10.1159/000135644. Epub 2008 Jun 2.
There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium.
Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2-3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up.
Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.
迫切需要识别处于痴呆前期的阿尔茨海默病（AD）患者，但目前缺乏经过验证的诊断方法。在本文中，我们介绍一项研究的背景、设计和方法，该研究旨在制定痴呆前期AD的临床标准。我们还展示了所纳入受试者的基线特征。该研究是多中心DESCRIPA项目的一部分，该项目正在欧洲阿尔茨海默病联盟网络内开展。
临床标准将基于一项对55岁以上非痴呆受试者进行的前瞻性队列研究，这些受试者被转诊至记忆门诊。在基线时，收集了一些AD的标志物和风险因素，包括人口统计学变量、日常生活活动能力指标、认知、神经影像学和基因标志物，以及血清和脑脊液标志物。受试者将在2至3年内每年进行重新评估，我们将评估哪些变量组合能在随访时最好地预测AD型痴呆。
在2003年至2005年期间，从20个记忆门诊纳入了881名受试者。受试者平均年龄为70.3岁，受教育年限为10.4年。简易精神状态检查表的平均得分为27.4。
