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γ-D-谷氨酰甘氨酸对海人藻酸和使君子氨酸受体作用的药理学分析

[Pharmacologic analysis of the effect of gamma-D-glutamylglycine on kainate and quisqualate receptors].

作者信息

Marchenko S M

出版信息

Neirofiziologiia. 1991;23(1):116-8.

PMID:1851965
Abstract

gamma-D-Glutamylglycine (DGG) influence on kainate- and quisqualate-activated currents in the Purkinje neurons from rat cerebellum was investigated. DGG caused a parallel shift of concentration dependences of kainate-activated current and a transient component of quisqualate-activated current to the right. Concentration dependence of the stationary component of quisqualate-activated current was shifted to the right by DGG and simultaneously its cooperativity decreased.

摘要

研究了γ-D-谷氨酰甘氨酸（DGG）对大鼠小脑浦肯野神经元中由海人藻酸和quisqualate激活的电流的影响。DGG使海人藻酸激活电流以及quisqualate激活电流的瞬态成分的浓度依赖性平行右移。DGG使quisqualate激活电流的稳态成分的浓度依赖性右移，同时其协同性降低。

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