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[大鼠小脑中海藻酸和使君子氨酸受体的分布]

[The distribution of kainate and quisqualate receptors in the rat cerebellum].

作者信息

Marchenko S M

出版信息

Neirofiziologiia. 1990;22(5):700-2.

PMID:2263299
Abstract

Sensitivity of isolated Purkinje neurons from rat cerebellum to agonists of excitatory amino acids was studied. Kainate and quisqualate activated inward currents in the most studied neurons. NMDA and APB were ineffective. Distribution of kainate and quisqualate receptors was different. Currents activated by kainate and quisqualate were not additive. Hypotheses allowing one to explain the observed results were discussed.

摘要

研究了从大鼠小脑分离出的浦肯野神经元对兴奋性氨基酸激动剂的敏感性。在所研究的大多数神经元中,海人酸和quisqualate激活内向电流。N-甲基-D-天冬氨酸和APB无效。海人酸和quisqualate受体的分布不同。海人酸和quisqualate激活的电流不是相加的。讨论了能够解释观察结果的假设。

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