Johnson Louise A, Jackson David G
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
Ann N Y Acad Sci. 2008;1131:119-33. doi: 10.1196/annals.1413.011.
The principal immune function of the afferent lymphatics is to bear antigen and leukocytes from peripheral tissues to the draining lymph nodes. Recent research has shown that passage of leukocytes into the afferent lymphatic capillaries is far from an indolent process; rather it is carefully orchestrated by an array of adhesion molecules, as well as by chemokines and their receptors. Here we review the current knowledge of leukocyte trans-lymphatic endothelial migration and its role in the development of an immune response.
输入淋巴管的主要免疫功能是将抗原和白细胞从外周组织输送至引流淋巴结。最近的研究表明，白细胞进入输入淋巴管毛细血管的过程绝非一个惰性过程；相反，它是由一系列粘附分子以及趋化因子及其受体精心调控的。在此，我们综述了目前关于白细胞经淋巴管内皮迁移及其在免疫反应发生中的作用的相关知识。
