Yeo Kim Pin, Angeli Veronique
Immunology Programme, Department of Microbiology and Immunology, Yoon Loo Lin School of Medicine, Life Science Institute, National University of Singapore , Singapore , Singapore.
Front Immunol. 2017 Feb 6;8:83. doi: 10.3389/fimmu.2017.00083. eCollection 2017.
Lymphatic vessels have been traditionally considered as passive transporters of fluid and lipids. However, it is apparent from recent literature that the function of lymphatic vessels is not only restricted to fluid balance homeostasis but also extends to regulation of immune cell trafficking, antigen presentation, tolerance, and immunity, all which may impact the progression of inflammatory responses and diseases such as cancer. The lymphatic system and the immune system are intimately connected, and there is emergent evidence for a crosstalk between T cell and lymphatic endothelial cell (LEC). This review describes how LECs in lymph nodes can affect multiple functional properties of T cells and the impact of these LEC-driven effects on adaptive immunity and, conversely, how T cells can modulate LEC growth. The significance of such crosstalk between T cells and LECs in cancer will also be discussed.
传统上，淋巴管被认为是液体和脂质的被动运输者。然而，从最近的文献中可以明显看出，淋巴管的功能不仅限于维持液体平衡稳态，还扩展到调节免疫细胞运输、抗原呈递、耐受性和免疫，所有这些都可能影响炎症反应和癌症等疾病的进展。淋巴系统和免疫系统密切相关，并且有新的证据表明T细胞与淋巴管内皮细胞（LEC）之间存在相互作用。这篇综述描述了淋巴结中的淋巴管内皮细胞如何影响T细胞的多种功能特性，以及这些由淋巴管内皮细胞驱动的效应如何影响适应性免疫，反之，T细胞如何调节淋巴管内皮细胞的生长。还将讨论T细胞与淋巴管内皮细胞之间的这种相互作用在癌症中的意义。
