杜英中鞣花酸衍生物和具有细胞毒性的葫芦素

Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii.

作者信息

Ito Aiko, Chai Hee-Byung, Lee Dongho, Kardono Leonardus B S, Riswan Soedarsono, Farnsworth Norman R, Cordell Geoffrey A, Pezzuto John M, Kinghorn A Douglas

机构信息

Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.

出版信息

Phytochemistry. 2002 Sep;61(2):171-4. doi: 10.1016/s0031-9422(02)00232-7.

DOI:10.1016/s0031-9422(02)00232-7

PMID:12169311

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4'-O-methylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (1) and 4,4'-O-dimethylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.

摘要

以KB（人口腔表皮样癌）细胞为监测指标，对杜英树皮进行生物测定导向研究，分离出两种葫芦素，即葫芦素D和葫芦素F作为细胞毒性成分，以及两种鞣花酸衍生物，4'-O-甲基鞣花酸3-(2",3"-二-O-乙酰基)-α-L-鼠李糖苷（1）和4,4'-O-二甲基鞣花酸3-(2",3"-二-O-乙酰基)-α-L-鼠李糖苷（2）。对这些化合物针对一组人肿瘤细胞系进行了评估。