Moribe Kunikazu, Wanawongthai Chalermphon, Shudo Jyutaro, Higashi Kenjirou, Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
Chem Pharm Bull (Tokyo). 2008 Jun;56(6):878-80. doi: 10.1248/cpb.56.878.
Morphology and surface states of colloidal probucol nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture into water were investigated by atomic force microscopy (AFM). The observed particles had core-shell structure, i.e. drug nanocrystals were covered with PVP and SDS complex. The AFM phase image and the force curve analyses indicated that probucol nanoparticles with PVP K17 showed layer structure, compared to those with PVPK12. The structural difference was explainable in terms of the molecular states of PVP-SDS complex on the particle surface. These findings support not only the mechanism of drug nanoparticle formation but also the in vivo absorption results with the almost same particle size of ca. 40 nm.
通过原子力显微镜（AFM）研究了将普罗布考/聚乙烯吡咯烷酮（PVP）/十二烷基硫酸钠（SDS）三元研磨混合物分散于水中后，胶体普罗布考纳米粒的形态和表面状态。观察到的颗粒具有核壳结构，即药物纳米晶体被PVP和SDS复合物覆盖。AFM相图像和力曲线分析表明，与含有PVP K12的普罗布考纳米粒相比，含有PVP K17的普罗布考纳米粒呈现层状结构。这种结构差异可以从颗粒表面PVP-SDS复合物的分子状态来解释。这些发现不仅支持了药物纳米粒的形成机制，也支持了体内吸收结果，即粒径几乎相同，约为40 nm。
