Pearce J M S
Department of Neurology, Hull Royal Infirmary, Hull, UK.
Eur Neurol. 2008;60(1):53-6. doi: 10.1159/000131715. Epub 2008 May 16.
The association of anaemia and gastro-intestinal abnormalities with disorders of the brain, spinal cord, and peripheral nerves has been recognized since the mid 19th century. In early reports interpretable as subacute combined degeneration, anaemia was overlooked, and conversely in Addison's and other early reports of pernicious anaemia, cord and nerve changes were not recorded. This paper shows that Lichtheim first combined the two observations, and illustrates the excellent descriptions in 1890 of James Putnam and Charles Dana. The most complete early account was that of Russell, Batten and Collier in 1900.
自19世纪中叶以来，人们就已认识到贫血及胃肠道异常与脑、脊髓和周围神经疾病之间的关联。在早期可解释为亚急性联合变性的报告中，贫血被忽视了；相反，在艾迪生病及其他早期恶性贫血报告中，脊髓和神经的变化未被记录。本文表明，利希海姆首次将这两种观察结果结合起来，并列举了1890年詹姆斯·普特南和查尔斯·达纳的精彩描述。最完整的早期记述是1900年拉塞尔、巴顿和科利尔所写的。
