Senol M G, Sonmez G, Ozdag F, Saracoglu M
Department of Neurology, GATA Haydarpasa Egitim Hastanesi, Noroloji Servisi, Kadikoy, Istanbul, Turkey.
Singapore Med J. 2008 Nov;49(11):e330-2.
Vitamin B12 deficiency causes haematological, gastrointestinal, psychiatric and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord, characterised by degeneration of the lateral and posterior columns, is often found due to vitamin B12 deficiency. We report SCD occurring in a 57-year-old man who presented with a 2.5-month history of gradually progressing tingling in the fingers and toes and neck ache. Laboratory data revealed vitamin B12 deficiency and magnetic resonance (MR) imaging of the cervical spinal cord demonstrated abnormal hyperintense signal changes on T2-weighted imaging of the posterior columns. In our case, follow-up MR imaging findings correlated well with clinical outcome after treatment with vitamin B12 supplements. Neurological symptoms in vitamin B12 deficiency are frequent. Early spinal MR imaging assists in the early diagnosis and treatment of the disease.
维生素B12缺乏会导致血液学、胃肠道、精神和神经疾病。脊髓亚急性联合变性（SCD）以侧柱和后柱变性为特征，常因维生素B12缺乏而出现。我们报告了一例57岁男性发生SCD，该患者有2.5个月逐渐进展的手指、脚趾刺痛和颈部疼痛病史。实验室检查显示维生素B12缺乏，颈椎脊髓磁共振成像（MR）显示后柱在T2加权成像上有异常高信号改变。在我们的病例中，随访MR成像结果与维生素B12补充治疗后的临床结果密切相关。维生素B12缺乏时神经症状很常见。早期脊髓MR成像有助于该病的早期诊断和治疗。
