Horiguchi Shigetoshi, Okamoto Yoshitaka, Yonekura Shuji, Okawa Toru, Kunii Naoki, Yamamoto Heizaburo, Sakurai Daiju, Hanazawa Toyoyuki
Department of Otolaryngology & Head and Neck Surgery, Graduate School of Medicine, Chiba University.
Arerugi. 2008 May;57(5):558-61.
Japanese cedar and cypress pollen share a common antigen. The cedar pollen season is followed by the cypress pollen season. However, both the clinical significance and involvement of cypress pollinosis in the treatment of the cedar pollinosis have not yet been clarified.
The clinical efficacy of sublingual immunotherapy with cedar pollen extract for cedar pollinosis was evaluated during the cypress pollen dispersal season in Japan. In addition, the change in cypress pollen specific IgE antibodies of the patients with cedar pollinosis was examined before and after the pollen season.
Sublingual immunotherapy with cedar pollen extract did not improve the clinical symptoms of the cedar pollinosis patients combined with cypress pollinosis in the cypress pollen season. The cypress pollen specific IgE antibodies were found to demonstrate significant seasonal changes.
The presence of cypress pollinosis should therefore be taken into consideration when planning the optimal treatment for cedar pollinosis. Sublingual immunotherapy with cedar pollen extract may not be effective for cypress pollinosis.
日本柳杉花粉和柏木花粉具有共同抗原。柳杉花粉季节之后是柏木花粉季节。然而，柏木花粉症在柳杉花粉症治疗中的临床意义及影响尚未明确。
在日本柏木花粉散播季节评估柳杉花粉提取物舌下免疫疗法对柳杉花粉症的临床疗效。此外，检测柳杉花粉症患者在花粉季节前后柏木花粉特异性IgE抗体的变化。
柳杉花粉提取物舌下免疫疗法在柏木花粉季节并未改善合并柏木花粉症的柳杉花粉症患者的临床症状。发现柏木花粉特异性IgE抗体呈现显著的季节性变化。
因此，在规划柳杉花粉症的最佳治疗方案时应考虑柏木花粉症的存在。柳杉花粉提取物舌下免疫疗法可能对柏木花粉症无效。
