Franko A J, Sharplin J, Ward W F, Hinz J M
Radiobiology, Cross Cancer Institute, Edmonton, Alberta, Canada.
Radiat Res. 1991 Jun;126(3):349-56.
Substantial differences between mouse strains have been reported in the lesions present in the lung during the early phase of radiation injury. Some strains show only classical pneumonitis, while other strains develop substantial fibrosis and hyaline membranes which contribute appreciably to respiratory insufficiency, in addition to pneumonitis. Other strains are intermediate between these extremes. These differences correlate with intrinsic differences in activities of lung plasminogen activator and angiotensin converting enzyme. The genetic basis of these differences was assessed by examining histologically the early reaction in lungs of seven murine hybrids available commercially after whole-thorax irradiation. Crosses between fibrosing and nonfibrosing parents were uniformly nonfibrosing, and crosses between fibrosing and intermediate parents were uniformly intermediate. No evidence of sex linkage was seen. Thus the phenotype in which fibrosis is found is controlled by autosomal recessive determinants. Strains prone to radiation-induced pulmonary fibrosis and hyaline membranes exhibited intrinsically lower activities of lung plasminogen activator and angiotensin converting enzyme than either the nonfibrosing strains or the nonfibrosing hybrid crosses. The median time of death of the hybrids was genetically determined primarily by the longest-lived parent regardless of the types of lesions expressed.
据报道，在辐射损伤早期阶段，不同小鼠品系肺部出现的病变存在显著差异。一些品系仅表现出典型的肺炎，而其他品系除肺炎外，还会发展出大量纤维化和透明膜，这对呼吸功能不全有显著影响。其他品系则介于这两种极端情况之间。这些差异与肺纤溶酶原激活剂和血管紧张素转换酶活性的内在差异相关。通过组织学检查七种市售小鼠杂种在全胸照射后肺部的早期反应，评估了这些差异的遗传基础。纤维化亲本与非纤维化亲本杂交的后代均为非纤维化，纤维化亲本与中间型亲本杂交的后代均为中间型。未发现性连锁的证据。因此，出现纤维化的表型由常染色体隐性决定因素控制。易发生辐射诱导的肺纤维化和透明膜的品系与非纤维化品系或非纤维化杂种杂交后代相比，其肺纤溶酶原激活剂和血管紧张素转换酶的内在活性较低。杂种的中位死亡时间主要由寿命最长的亲本通过遗传决定，而与所表现出的病变类型无关。
