Stirling H F, Darling J A, Barr D G
Royal Hospital for Sick Children, Edinburgh, Scotland, UK.
Acta Paediatr Scand. 1991 Mar;80(3):333-8. doi: 10.1111/j.1651-2227.1991.tb11858.x.
Highly purified bovine parathyroid hormone (PTH) was given by intravenous bolus injection to patients being investigated for disorders of mineral metabolism, and to adult volunteer controls. Plasma cyclic AMP measured basally and at 10 min gave reliable discrimination between the normal response and cases of pseudohypoparathyroidism. Infants under 3 months of age tended to have higher basal levels of cAMP and a flatter pattern of response to the dose of PTH used. This simplified test procedure in children offers considerable advantages over previous tests of PTH responsiveness which involve urine collections and multiple blood sampling. It is suitable for selective screening of individuals suspected of pseudohypoparathyroidism on the basis of their family history or physical abnormalities.
将高度纯化的牛甲状旁腺激素（PTH）通过静脉推注给予正在接受矿物质代谢紊乱调查的患者以及成年志愿者对照。基础状态下和10分钟时测量的血浆环磷酸腺苷（cAMP）能够可靠地区分正常反应和假性甲状旁腺功能减退病例。3个月以下的婴儿往往具有较高的基础cAMP水平，并且对所用PTH剂量的反应模式较为平缓。这种针对儿童的简化检测程序相较于先前涉及尿液收集和多次采血的PTH反应性检测具有相当大的优势。它适用于根据家族史或身体异常情况对疑似假性甲状旁腺功能减退的个体进行选择性筛查。
