Kawabe Kouichi, Miyamoto Eri
Graduate School of Literature and Human Sciences, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka, Japan.
Neuroreport. 2008 Jun 11;19(9):969-73. doi: 10.1097/WNR.0b013e328302ee31.
This study was carried out to investigate the long-term effects of chronic neonatal antagonism of N-methyl-D-aspartate (NMDA) receptors, a subtype of glutamate receptors, on working memory. Rats were tested on the delayed nonmatching-to-position task in adulthood after repeated treatment of a noncompetitive NMDA antagonist MK-801 in postnatal days 7-20. As a result, this treatment led to deficits in learning and/or performance of delayed nonmatching-to-position responses, suggesting that chronic neonatal NMDA antagonism persistently impairs working memory. Furthermore, it decreased body and brain weight, and induced stereotyped head-rotation behavior. As working memory deficits are shown in several mental disorders such as schizophrenia and developmental disorders, rats with chronic neonatal NMDA antagonism might be useful for a better understanding of these disorders.
本研究旨在探讨慢性新生期拮抗N-甲基-D-天冬氨酸（NMDA）受体（谷氨酸受体的一种亚型）对工作记忆的长期影响。在出生后第7至20天对大鼠反复给予非竞争性NMDA拮抗剂MK-801进行处理后，在成年期对其进行延迟位置匹配任务测试。结果，这种处理导致延迟位置匹配反应的学习和/或表现出现缺陷，表明慢性新生期NMDA拮抗作用持续损害工作记忆。此外，它还降低了体重和脑重，并诱发了刻板的头部旋转行为。由于在精神分裂症和发育障碍等几种精神疾病中都出现了工作记忆缺陷，慢性新生期NMDA拮抗的大鼠可能有助于更好地理解这些疾病。
