Su Yun-Ai, Wang Xiao-Dong, Li Ji-Tao, Guo Chun-Mei, Feng Yu, Yang Yang, Huang Run-Hu, Si Tian-Mei
Key Laboratory of Mental Health of National Health Ministry, Institute of Mental Health, Peking University, Beijing, China.
Neuroreport. 2011 Jun 11;22(8):402-6. doi: 10.1097/WNR.0b013e328346e154.
The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats.
N-甲基-D-天冬氨酸受体在发育可塑性中起关键作用。有证据表明，新生大鼠暴露于N-甲基-D-天冬氨酸受体拮抗剂会损害成年大鼠的认知能力。本研究调查了新生大鼠接受MK-801治疗是否会对青春期和成年雌性大鼠的工作记忆和感觉运动门控产生长期和年龄特异性影响。在出生后第5 - 14天用MK-801治疗后，雌性大鼠在青春期（出生后第35 - 42天）表现出轻微的工作记忆受损。相比之下，成年（出生后第63 - 70天）雌性大鼠的工作记忆明显受到干扰。然而，两个年龄段的前脉冲抑制和惊吓幅度均未受到显著影响。这些发现表明，新生大鼠接受MK-801治疗会引发工作记忆缺陷，尤其是在青春期后的雌性大鼠中。
