绿茶儿茶素在前列腺癌TRAMP模型中抑制DNA合成标志物MCM7。
Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
作者信息
McCarthy Susan, Caporali Andrea, Enkemann Steve, Scaltriti Maurizio, Eschrich Steve, Davalli Pierpaola, Corti Arnaldo, Lee Alice, Sung Jimmy, Yeatman Timothy J, Bettuzzi Saverio
机构信息
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA.
出版信息
Mol Oncol. 2007 Sep;1(2):196-204. doi: 10.1016/j.molonc.2007.05.007.
Abstract
Green tea catechins (GTCs) exert chemopreventive effects in many cancer models. Several studies implicate the DNA synthesis marker minichromosome maintenance protein 7 (MCM7) in prostate cancer progression, growth and invasion; representing a novel therapeutic target. In this study, we investigated the effect of GTCs on MCM7 expression in the transgenic adenocarcinoma mouse prostate model (TRAMP). DNA microarray, immunohistochemistry and western blot analysis showed that GTCs significantly suppressed MCM7 in the TRAMP mice treated with GTCs. Our study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by GTCs. Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role.
摘要
绿茶儿茶素（GTCs）在许多癌症模型中发挥化学预防作用。多项研究表明，DNA合成标志物微小染色体维持蛋白7（MCM7）与前列腺癌的进展、生长和侵袭有关；它是一个新的治疗靶点。在本研究中，我们调查了GTCs对转基因腺癌小鼠前列腺模型（TRAMP）中MCM7表达的影响。DNA微阵列、免疫组织化学和蛋白质印迹分析表明，GTCs显著抑制了接受GTCs治疗的TRAMP小鼠中的MCM7。我们的研究表明，细胞DNA复制因子MCM7参与前列腺癌（CaP），且GTCs可降低MCM7基因的表达。这些结果共同表明，GTCs在CaP化学预防中可能发挥作用，其中MCM7起着关键作用。
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