综述：绿茶多酚在前列腺癌化学预防中的作用：临床前和临床研究。
Review: green tea polyphenols in chemoprevention of prostate cancer: preclinical and clinical studies.
机构信息
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
Nutr Cancer. 2009;61(6):836-41. doi: 10.1080/01635580903285056.
Abstract
The prevention of prostate cancer (PCa) is a crucial medical challenge in developed countries. PCa remains surrounded by puzzles in spite of the considerable progress in research, diagnosis, and treatment. It is an ideal target for chemoprevention, as clinically significant PCa usually requires more than two decades for development. Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases including cancer. In this review, we highlight the evidences of green tea polyphenols from preclinical and clinical studies in the chemoprevention/chemotherapy of PCa.
摘要
预防前列腺癌（PCa）是发达国家面临的一项重要医学挑战。尽管在研究、诊断和治疗方面取得了相当大的进展，但 PCa 仍然存在许多未解之谜。由于临床上有意义的 PCa 通常需要超过二十年的时间才能发展，因此它是化学预防的理想目标。绿茶及其主要成分表没食子儿茶素没食子酸酯（EGCG）已被广泛研究作为治疗多种疾病（包括癌症）的潜在药物。在这篇综述中，我们强调了来自临床前和临床研究的绿茶多酚在 PCa 的化学预防/化疗中的证据。
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本文引用的文献
1
Cancer statistics, 2009.
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.
2
Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
Mol Oncol. 2007 Sep;1(2):196-204. doi: 10.1016/j.molonc.2007.05.007.
3
Chemoprevention of human prostate cancer by green tea catechins: two years later. A follow-up update.
Eur Urol. 2008 Aug;54(2):472-3. doi: 10.1016/j.eururo.2008.03.100. Epub 2008 Apr 4.
4
Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.
Pharm Res. 2008 Sep;25(9):2135-42. doi: 10.1007/s11095-008-9553-z. Epub 2008 Mar 4.
5
Cancer chemoprevention through dietary antioxidants: progress and promise.
Antioxid Redox Signal. 2008 Mar;10(3):475-510. doi: 10.1089/ars.2007.1740.
6
Chemoprevention of prostate cancer through dietary agents: progress and promise.
Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2193-203. doi: 10.1158/1055-9965.EPI-06-0942.
7
Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis.
Oncogene. 2008 Mar 27;27(14):2055-63. doi: 10.1038/sj.onc.1210840. Epub 2007 Nov 12.
8
Green tea consumption and prostate cancer risk in Japanese men: a prospective study.
Am J Epidemiol. 2008 Jan 1;167(1):71-7. doi: 10.1093/aje/kwm249. Epub 2007 Sep 29.
9
Epigallocatechin-3-Gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: mechanisms of action.
Prostate. 2007 Oct 1;67(14):1576-89. doi: 10.1002/pros.20643.
10
Tea polyphenols for health promotion.
Life Sci. 2007 Jul 26;81(7):519-33. doi: 10.1016/j.lfs.2007.06.011. Epub 2007 Jun 28.
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