14号染色体长臂杂合性缺失与头颈部鳞状细胞癌的不良预后相关。
Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas.
作者信息
Pehlivan Davut, Gunduz Esra, Gunduz Mehmet, Nagatsuka Hitoshi, Beder Levent Bekir, Cengiz Beyhan, Rivera Rosario S, Fukushima Kunihiro, Palanduz Sukru, Ozturk Sukru, Yamanaka Noboru, Shimizu Kenji
机构信息
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikatacho 2-5-1, Okayama 700-8525, Japan.
出版信息
J Cancer Res Clin Oncol. 2008 Dec;134(12):1267-76. doi: 10.1007/s00432-008-0423-1. Epub 2008 Jun 3.
PURPOSE AND METHODS
Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.
RESULTS
Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival.
CONCLUSIONS
The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.
目的和方法
染色体位点的杂合性缺失（LOH）表明存在一个失活的肿瘤抑制基因（TSG）。TSG的失活在头颈部鳞状细胞癌（HNSCC）的肿瘤发生中起功能性作用。基于最近在14号染色体上存在一个假定TSG的证据，我们使用八个多态性微卫星标记物在50例HNSCC病例中检测了14号染色体长臂（14q）上的LOH。
结果
检测到三个区域具有高LOH率，包括14q21.2 - 22.3（42.5%）、14q31（55%）和14q32.1（37%）。通过统计分析研究了LOH与临床病理结果之间的相关性。在最高LOH标记物与总体生存率和无病生存率之间观察到强相关性。
结论
结果表明14号染色体的远端部分可能存在一个TSG，其可能导致HNSCC的发生和/或进展。该区域出现了几个基因，如CHES1、BMP4、SAV和PNN，作为候选肿瘤抑制基因。
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