Hertel F, Züchner M, Decker C, Schill S, Bosniak I, Bettag M
Department of Neurosurgery, SHG-Klinik, Idar-Oberstein, Germany.
Minim Invasive Neurosurg. 2008 Jun;51(3):147-53. doi: 10.1055/s-2008-1065337.
In spite of the development of approximately 200 different shunt systems within the last 50 years, overdrainage and valve obstructions are still major problems in the current treatment of hydrocephalus. In 1994, a new gravitational valve with different opening pressures (depending upon the patient's posture) and a big contact area to CSF was introduced by Miethke and co-workers (DSV). We report about a single institution's experience in the treatment of 169 adult patients with different kinds of hydrocephalus with this valve.
We retrospectively reviewed the clinical and radiological data of all patients who were treated with a DSV between 1998 and 2005 at our institution. A telephone interview was perfomed at the end of the study, to determine the overall shunt survival. We analysed the outcome and the shunt-related complications.
Among 169 patients with DSV, we had 70 patients with normal pressure hydrocephalus (NPH), 40 patients with communicating hydrocephalus due to SAH, 31 patients with communicating hydrocephalus not due to SAH and 28 patients with occlusive hydrocephalus. We had a rate of shunt responders of 93.2%, an overdrainage rate of 3.2% and no valve obstruction in the whole series. The overall shunt survival was 81% after 82 months (mean follow-up: 47.6 months). All implantations were performed by the whole staff, as well as by residents of the neurosurgical department.
Among the currently available shunt systems, this series is one with the lowest complication rates due to overdrainage and valve obstructions. In patients with NPH, where low opening pressures are essential, the DSV seems to bear an advantage because of a high drainage rate and, in spite of this, a low rate of overdrainage. Even in patients with relatively high CSF protein content, we did not observe any valve obstruction. This study was an open field analysis providing data about the current complication rates of hydrocephalus treatment with this shunt system, outside of a specialized hydrocephalus team or a prospective study trial. However, this study is a retrospective analysis and a prospective randomized controlled trial is required for the comparison of these valves with other shunt systems, such as programmable and flow-controlled ones is required for the future.
尽管在过去50年里已研发出约200种不同的分流系统,但在目前的脑积水治疗中,引流过度和阀门阻塞仍是主要问题。1994年,米特克及其同事推出了一种新型重力阀(DSV),其开启压力不同(取决于患者体位),与脑脊液的接触面积较大。我们报告了一家机构使用该阀门治疗169例不同类型脑积水成年患者的经验。
我们回顾性分析了1998年至2005年在本机构接受DSV治疗的所有患者的临床和放射学数据。在研究结束时进行了电话随访,以确定分流器的总体使用寿命。我们分析了治疗结果和与分流器相关的并发症。
在169例使用DSV的患者中,有70例为正常压力脑积水(NPH)患者,40例为因蛛网膜下腔出血(SAH)导致的交通性脑积水患者,31例为非SAH导致的交通性脑积水患者,28例为梗阻性脑积水患者。整个系列中,分流反应者的比例为93.2%,引流过度率为3.2%,未出现阀门阻塞情况。82个月后的总体分流器使用寿命为81%(平均随访时间:47.6个月)。所有植入手术均由全体工作人员以及神经外科住院医师完成。
在目前可用的分流系统中,本系列因引流过度和阀门阻塞导致的并发症发生率是最低的之一。在NPH患者中,低开启压力至关重要,DSV似乎具有优势,因为其引流率高,尽管如此,引流过度率却很低。即使在脑脊液蛋白含量相对较高的患者中,我们也未观察到任何阀门阻塞情况。本研究是一项开放性分析,提供了关于在专业脑积水治疗团队之外或前瞻性研究试验之外使用该分流系统治疗脑积水的当前并发症发生率的数据。然而,本研究是一项回顾性分析,未来需要进行前瞻性随机对照试验,以将这些阀门与其他分流系统(如可编程和流量控制的分流系统)进行比较。