Rasche-Schürmann Celine C, Picksak Gesine, Stichtenoth Dirk O
Institut für Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1,30625 Hannover.
Med Monatsschr Pharm. 2008 Jan;31(1):25-7.
Myopathy is the most serious, dose dependent adverse reaction of statins and may lead to rhabdomyolysis and death. Clinical symptoms are muscle pain, weakness and muscle cramps, main laboratory finding is an increase in serum creatine kinase (CK). If myopathy symptoms are present or CK levels are greater than 5 times the upper limits of normal, statin therapy should be discontinued. In case of an asymptomatic CK increase below 5 times the upper limits of normal, therapy can be continued with CK monitoring.
肌病是他汀类药物最严重的剂量依赖性不良反应，可能导致横纹肌溶解和死亡。临床症状为肌肉疼痛、无力和肌肉痉挛，主要实验室检查结果是血清肌酸激酶（CK）升高。如果出现肌病症状或CK水平高于正常上限5倍，应停用他汀类药物治疗。对于CK无症状升高且低于正常上限5倍的情况，可以在监测CK的同时继续治疗。
