氨酰-tRNA合成酶复合物：揭示的分子多任务功能
Aminoacyl-tRNA synthetase complexes: molecular multitasking revealed.
作者信息
Hausmann Corinne D, Ibba Michael
机构信息
Department of Microbiology, The Ohio State University, Columbus, OH 43210-1292, USA.
出版信息
FEMS Microbiol Rev. 2008 Jul;32(4):705-21. doi: 10.1111/j.1574-6976.2008.00119.x. Epub 2008 Jun 3.
Abstract
The accurate synthesis of proteins, dictated by the corresponding nucleotide sequence encoded in mRNA, is essential for cell growth and survival. Central to this process are the aminoacyl-tRNA synthetases (aaRSs), which provide amino acid substrates for the growing polypeptide chain in the form of aminoacyl-tRNAs. The aaRSs are essential for coupling the correct amino acid and tRNA molecules, but are also known to associate in higher order complexes with proteins involved in processes beyond translation. Multiprotein complexes containing aaRSs are found in all three domains of life playing roles in splicing, apoptosis, viral assembly, and regulation of transcription and translation. An overview of the complexes aaRSs form in all domains of life is presented, demonstrating the extensive network of connections between the translational machinery and cellular components involved in a myriad of essential processes beyond protein synthesis.
摘要
由mRNA中编码的相应核苷酸序列决定的蛋白质精确合成，对于细胞生长和存活至关重要。这一过程的核心是氨酰-tRNA合成酶（aaRSs），它们以氨酰-tRNA的形式为正在生长的多肽链提供氨基酸底物。aaRSs对于连接正确的氨基酸和tRNA分子至关重要，但也已知它们会与翻译以外过程中涉及的蛋白质形成更高阶的复合物。含有aaRSs的多蛋白复合物存在于生命的所有三个域中，在剪接、细胞凋亡、病毒组装以及转录和翻译调控中发挥作用。本文概述了aaRSs在生命所有域中形成的复合物，展示了翻译机制与参与蛋白质合成以外众多基本过程的细胞成分之间广泛的连接网络。
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